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- Title
Preparation and in-vitro/ in-vivo evaluation of curcumin nanosuspension with solubility enhancement.
- Authors
Li, Xin; Yuan, Huiling; Zhang, Caiyun; Chen, Weidong; Cheng, Weiye; Chen, Xin; Ye, Xi
- Abstract
Objectives We developed Cur nanosuspension (Cur- NS) with PVPK30 and SDS as stabilizers to improve poor water solubility and short biological half-time of Cur. Methods Physicochemical characterization of Cur- NS was characterized systematically. The in-vitro dissolution, cytotoxicity and in-vivo pharmacokinetic experiments of Cur- NS were also evaluated. Key findings Scanning electron microscope indicated that the morphologies of Cur- NS were spherical or ellipsoidal in shape. X-ray diffraction verified that Cur was successfully developed as nanoparticles with an amorphous phase in Cur- NS. Fourier transform infrared spectroscopy suggested there was no degradation about Cur in the Cur- NS. Furthermore, the in-vitro study showed that the cumulative release of the Cur- NS was 82.16 ± 2.62% within 34 h and the cytotoxicity of the Cur- NS against HepG2 cells was much better than raw Cur. Besides, in-vivo pharmacokinetics in rats by intravenous injection displayed that the in- vivo process of Cur- NS pertained to two-compartment model. Meanwhile, the t1/2 and AUC0- t of Cur- NS were enhanced by 11.0-fold and 4.2-fold comparing to Cur solution. Conclusions The Cur- NS significantly increased the water solubility and half-time of Cur, suggesting its potential as a nanocarrier in the delivery of Cur for future clinical application.
- Subjects
STABILIZING agents; PHARMACOKINETICS; FOURIER transform infrared spectroscopy; NANOPARTICLES; LABORATORY rats; INTRAVENOUS injections
- Publication
Journal of Pharmacy & Pharmacology, 2016, Vol 68, Issue 8, p980
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/jphp.12575