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- Title
Improvement of hyperglycaemia and metabolic syndromes in type 2 diabetic KKAy mice by oral treatment with [meso-tetrakis(4-sulfonatophenyl) porphyrinato]oxovanadium(IV)(4–) complex.
- Authors
Tapan Kumar Saha; Yutaka Yoshikawa; Hiromu Sakurai
- Abstract
Recently, we reported that [meso-tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadium(IV)(4–), VO(tpps), shows in-vitro insulin-mimetic and in-vivo anti-diabetic activity in streptozotocin (STZ)-induced type 1 diabetic mice. This result prompted us to examine its ability in type 2 diabetic model KKAy mice with insulin resistance. We studied the in-vivo anti-diabetic activity of VO(tpps), compared with that of vanadium(IV) oxide sulfate, VS, as control. Both compounds were orally administered at doses of 5–10 mg (0.1–0.2 mmol) V/kg body weight to the KKAy mice for 28 days. VO(tpps) normalized the hyperglycaemia within 15 days, while VS lowered the blood glucose concentration only by a small degree. In addition, metabolic syndromes characterized by insulin and leptin resistance were significantly improved in VO(tpps)-treated KKAy mice compared with those treated with VS. The improvement in diabetes was validated by oral glucose tolerance test and decrease in HbA1c concentration. Based on these observations, VO(tpps) is proposed to be an orally active oxovanadium(IV)–porphyrin complex for treating not only type 2 diabetes but also metabolic syndromes in animals.
- Subjects
HYPOGLYCEMIC agents; PEOPLE with diabetes; INSULIN; ENDOCRINE diseases
- Publication
Journal of Pharmacy & Pharmacology, 2007, Vol 59, Issue 3, p437
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1211/jpp.59.3.0014