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- Title
In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin.
- Authors
Wendy W. J. van de Sande; Ahmed H. Fahal; Thomas V. Riley; Henri Verbrugh; Alex van Belkum
- Abstract
<sec><st>Objectives</st> Eumycetoma caused by <it>Madurella mycetomatis</it> is treated with surgery and high doses of itraconazole and ketoconazole. These agents are toxic, and new therapies are required. </sec> <sec><st>Methods</st> MICs were determined for artemisinin and tea tree oil, two natural herbal compounds. </sec> <sec><st>Results</st> Artemisinin was not active against <it>M. mycetomatis</it>, but tea tree oil did inhibit its growth. Since tea tree oil's prime component easily penetrates the skin, tea tree oil could be a useful agent in the treatment of eumycetoma. </sec> <sec><st>Conclusions</st> Tea tree oil is active <it>in vitro</it> against <it>M. mycetomatis</it>. </sec>
- Subjects
LEPTOSPERMUM; TEA tree oil; ANTIFUNGAL agents; KETOCONAZOLE
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2007, Vol 59, Issue 3, p553
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkl526