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- Title
The relationship between trends in macrolide use and resistance to macrolides of common respiratory pathogens.
- Authors
Čižman, Milan; Pokorn, Marko; Seme, Katja; Oražem, Andreja; Paragi, Metka
- Abstract
The correlation between increased macrolide consumption and the resistance of Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to macrolides in Slovenia from 1994 to 1999 was evaluated. The outpatient consumption of macrolides increased from 1.89 to 3.84 defined daily doses (DDD)/1000 inhabitants/day during the observation period. This increase in macrolide consumption was paralleled by a steady increase in macrolide resistance in S. pyogenes (from 0 to 7.4%, r = 0.90, P = 0.014) and upper respiratory S. pneumoniae isolates (from 0 to 9%, r = 0.82, P = 0.044). In other pathogens studied, no significant increase was detected.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2001, Vol 47, Issue 4, p475
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/47.4.475