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- Title
Axe: rapid, competitive sequence read demultiplexing using a trie.
- Authors
Murray, Kevin D; Borevitz, Justin O
- Abstract
Summary We describe a rapid algorithm for demultiplexing DNA sequence reads with in-read indices. Axe selects the optimal index present in a sequence read, even in the presence of sequencing errors. The algorithm is able to handle combinatorial indexing, indices of differing length and several mismatches per index sequence. Availability and implementation Axe is implemented in C, and is used as a command-line program on Unix-like systems. Axe is available online at https://github.com/kdmurray91/axe, and is available in Debian/Ubuntu distributions of GNU/Linux as the package axe-demultiplexer. Supplementary information Supplementary data are available at Bioinformatics online
- Subjects
DEMULTIPLEXING; NUCLEOTIDE sequencing; HAMMING distance; COMBINATORIAL optimization; DNA fingerprinting
- Publication
Bioinformatics, 2018, Vol 34, Issue 22, p3924
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/bty432