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- Title
Population-Genetic Structure of Chuvash Populations Inferred from the Data on Eight DNA Loci of the Nuclear Genome.
- Authors
Khusnutdinova, E. K.; Victorova, T. V.; Akhmetova, V. L.; Mustafina, O. E.; Fatkhlislamova, R. I.; Balanovskaya, E. V.; Petrova, N. V.; Makarov, S. V.; Kravchuk, O. I.; Pai, G. V.; Ginter, E. K.
- Abstract
Population-genetic study of indigenous populations representing three ethnic Chuvash group: highland (Cheboksarsk and Morgaush district), lowland (Kanash district) and mid-lowland (Marposad district). Eight polymorphic DNA loci of the nuclear genome (VNTR/PAH, STR/PAH, VNTR/ApoB, VNTR/DAT1, APF, VNTR/eNOS, IVS6aGATT, and KM.19/PstI) were examined in the population of each district. For each of the four population, we estimated the allele and genotype frequency distributions at each polymorphic system, heterozygosities HS and between-population differences FST. In the combined Chuvash sample, <MATH>\bar H_S</MATH> = 0.464 and <MATH>\bar F_ST</MATH> = 0.006. Loci VNTR(DAT) and VNTR(ApoB) showed highest between-population differentiation (0.009 ≤ FST ≤ 0.012), and loci IVS6aGATT, APF, VNTR (eNOS), and D7S23(KM.19), lowest differentiation (0.001 ≤ FST ≤ 0.003). Analysis of genetic distances revealed somewhat higher genetic similarity between the Cheboksarsk and Morgaush populations belonging to the highland Chuvash group, whereas the highland Chuvash population from the Marposad district, which belong to the mid-lowland group, was more distant from the former populations.
- Subjects
RUSSIA; CHUVASH (Turkic people); ETHNOLOGY; INDIGENOUS peoples; GENETIC research; POPULATION genetics; GENETIC polymorphisms; GENOMICS; MOLECULAR genetics; NUCLEOTIDE sequence; DISTRIBUTION (Probability theory)
- Publication
Russian Journal of Genetics, 2003, Vol 39, Issue 11, p1313
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1023/B:RUGE.0000004147.09917.b7