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- Title
Modelling body mass index and endometrial cancer risk in a pooled-analysis of three case-control studies.
- Authors
Rota, M; Rumi, F; Bagnardi, V; Dal Maso, L; Zucchetto, A; Levi, F; La Vecchia, C; Tavani, A
- Abstract
<bold>Objective: </bold>To quantify the relation between body mass index (BMI) and endometrial cancer risk, and to describe the shape of such a relation.<bold>Design: </bold>Pooled analysis of three hospital-based case-control studies.<bold>Setting: </bold>Italy and Switzerland.<bold>Population: </bold>A total of 1449 women with endometrial cancer and 3811 controls.<bold>Methods: </bold>Multivariate odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from logistic regression models. The shape of the relation was determined using a class of flexible regression models.<bold>Main Outcome Measure: </bold>The relation of BMI with endometrial cancer.<bold>Results: </bold>Compared with women with BMI 18.5 to <25 kg/m(2) , the odds ratio was 5.73 (95% CI 4.28-7.68) for women with a BMI ≥35 kg/m(2) . The odds ratios were 1.10 (95% CI 1.09-1.12) and 1.63 (95% CI 1.52-1.75) respectively for an increment of BMI of 1 and 5 units. The relation was stronger in never-users of oral contraceptives (OR 3.35, 95% CI 2.78-4.03, for BMI ≥30 versus <25 kg/m(2) ) than in users (OR 1.22, 95% CI 0.56-2.67), and in women with diabetes (OR 8.10, 95% CI 4.10-16.01, for BMI ≥30 versus <25 kg/m(2) ) than in those without diabetes (OR 2.95, 95% CI 2.44-3.56). The relation was best fitted by a cubic model, although after the exclusion of the 5% upper and lower tails, it was best fitted by a linear model.<bold>Conclusions: </bold>The results of this study confirm a role of elevated BMI in the aetiology of endometrial cancer and suggest that the risk in obese women increases in a cubic nonlinear fashion. The relation was stronger in never-users of oral contraceptives and in women with diabetes.
- Subjects
BODY mass index; ENDOMETRIAL cancer risk factors; CANCER patients; ORAL contraceptives; DIABETES; OVERWEIGHT women
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2016, Vol 123, Issue 2, p285
- ISSN
1470-0328
- Publication type
journal article
- DOI
10.1111/1471-0528.13717