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- Title
Change in CRT gene sequence of Plasmodium falsiparum as a chloroquen resistant in Iraqi patients.
- Authors
ZGHAIR, ABDULRAZZAQ NEAMAH; MOHAMMED, NAZAR SH.; MUHSIN, SALWA S.
- Abstract
This study was conducted on (20) individuals whose ages ranged between (9-15) years and suspected to be infected with malaria in Qanaqin and Al-Saadiya towns / Diala province in Iraq during the period from1st June 2018 to 15th may 2019. The results showed that 9 (45%) of them were positive for plasmodium falciparum by using ELISA and IFAT techniques. Conventional PCR was used to determine the genotypes of the parasite. The primers used included forward primer ACTCTGTAGTTTGTAGAGATGCAA and reverse primer ACGGCACATTATCTCACCGTT, in the product of 504 length. Mutations occurred in Iraqi patients infected with chloroquine resistance (CRT) P. falciparum genes. The AAA changed to ATA and AAA to ACA respectively.
- Subjects
PLASMODIUM; CHLOROQUINE; DRUG resistance; ENZYME-linked immunosorbent assay; GENOTYPES
- Publication
International Journal of Pharmaceutical Research (09752366), 2020, Vol 12, Issue 2, p610
- ISSN
0975-2366
- Publication type
Article
- DOI
10.31838/ijpr/2020.12.02.0069