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- Title
Atorvastatin loading before percutaneous coronary intervention down-regulates Toll-like receptor4 expression and ameliorates myocardial injury markers.
- Authors
MAJEED, SAHAR A.; HADI, NAJAH R.; AMBER, KHALID I.; FATIMA, GHIZAL; REGEEB, AHMED N.; YOUSIF, NASSER GHALY; SINGH, RAM
- Abstract
The aim of the study was to assess the activity of pre-PCI atorvastatin reload on the acute inflammatory responses and in Toll-Like Receptor 4 expressions with its downstream signaling. A double-blind randomized prospective study, 30 patients who received low dose atorvastatin 40 mg/day without reload. While, 30 patients who were already on the usual dose of atorvastatin with further 80 mg & 40 mg at 12 and 2 hrs before PCI respectively. TLR4 expression in peripheral monocyte investigate by flow cytometry, and cardiac troponin I, CK-MB, HsCRP and HMG-BOX protein by ELISA technique immediately before and at 4 hrs, 12 hrs. After PCI. Stent implantation was associated with an elevation in TLR 4 expression in peripheral monocyte of both study groups after stenting with higher expression level was found among control group (p<0.05) at 4 hr and 12 hr post-PCI. HsCRP, HMGbox1protein were lower in atorvastatin reload group (p<0.05), and the myocardial injury markers (CKMB, troponin I) were significantly higher among the control group than atorvastatin reload group (p<0.05). Atorvastatin attenuated toll-like receptor 4 expressions on peripheral monocyte subsequently its downstream effects HsCRP and HMGBOX1-protein.
- Subjects
ATORVASTATIN; PERCUTANEOUS coronary intervention; MYOCARDIAL infarction; MONOCYTES; ENZYME-linked immunosorbent assay
- Publication
International Journal of Pharmaceutical Research (09752366), 2019, Vol 11, Issue 3, p346
- ISSN
0975-2366
- Publication type
Article