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- Title
Opinion: Taking our breath away: dendritic cells in the pathogenesis of asthma.
- Authors
Lambrecht, Bart N.; Hammad, Hamida
- Abstract
Dendritic cells (DCs) are mainly known for their capacity to induce primary immune responses. Here, we propose that DCs are similarly essential for controlling effector T-cell responses and, therefore, might have a role in T-cell-mediated diseases. In the case of asthma, airway DCs are essential for controlling T helper 2 (TH2)-dependent eosinophilic airway inflammation. Therefore, interfering with DC function could be of therapeutic benefit.
- Subjects
DENDRITIC cells; ASTHMA; IMMUNE response; T cells; AIRWAY (Anatomy)
- Publication
Nature Reviews Immunology, 2003, Vol 3, Issue 12, p994
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri1249