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- Title
Derivative Spectrophotometric Method Development and Validation for the Estimation of Evogliptin Tartrate in Pharmaceutical Dosage Form.
- Authors
Patel, Khushbu; Shah, Ujash; Joshi, Hirak; Patel, C. N.
- Abstract
Aim: A simple and economic method was developed as a derivative spectrophotometric study for estimation of evogliptin tartrate in the tablet dosage form. The developed derivative method was validated as per the ICH guideline. Materials and Methods: The maximum absorption of evogliptin tartare was found to be 267 nm and its first and second derivative wavelengths were measured at 275 nm and 277 nm respectively. Water was used as a solvent for all measurements. Results: The developed method was shown linear in the concentration range of 20-120 µg/ml for evogliptin tartrate and shows a good correlation coefficient. The precision of the developed method was less than the maximum allowable limit (% RSD < 2) specified by the ICH guidelines. Excellent % recovery (98% - 101%) with less than 2% RSD value indicates method was accurate. Conclusion: The developed UV - Visible method was simple eco-friendly, precise and accurate as per ICH guidelines. The proposed method will use in quality control for routine analysis of evogliptin tartrate in the pharmaceutical dosage form.
- Subjects
DOSAGE forms of drugs; QUALITY control; WATER use; STATISTICAL correlation
- Publication
Indian Journal of Pharmaceutical Education & Research, 2023, Vol 57, Issue 1, p228
- ISSN
0019-5464
- Publication type
Article
- DOI
10.5530/001954640245