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- Title
NEW INSIGHTS ON SOME 6-CHLORO-9H-CARBAZOL DERIVATIVES CONCERNING THEIR IN VITRO ANTIOXIDANT CAPACITY AND IN VIVO CYTOTOXICITY.
- Authors
BORDEI (TELEHOIU), ALEXANDRA TEODORA; COSTEA, TEODORA; LIMBAN, CARMEN; NUȚĂ, DIANA CAMELIA; GÎRD, CERASELA ELENA; ZARAFU, IRINA; BALACI, TEODORA DALILA; KARAMPELAS, OANA; ANCUCEANU, ROBERT VIOREL
- Abstract
According to recent research, both carbazol and 1,3,4-oxadiazol derivatives are known for their antioxidant properties. The aim of our research was the evaluation of antioxidant activity and in vivo cytotoxicity of some new heterocyclic compounds, which both contain pharmacophore groups. The antioxidant activity was evaluated by means of scavenger activity towards 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•+) free radicals. In vivo cytotoxicity was assessed using Artemia franciscana nauplii lethality bioassay. Our results have shown that the analysed compounds can be further used for their antioxidant capacity. For the analysed concentration interval (25 - 1000 μM), the scavenger capacity towards ABTS•+ free radical was higher compared to the DPPH assay. All tested compounds showed an adequate safety profile. Further research is needed for evaluation of in vivo antioxidant effects of tested compounds and furthermore their safety via pre-clinical tests.
- Subjects
OXIDANT status; FREE radicals; HETEROCYCLIC compounds; ARTEMIA; BIOLOGICAL assay
- Publication
Farmacia, 2021, Vol 69, Issue 3, p475
- ISSN
0014-8237
- Publication type
Article
- DOI
10.31925/farmacia.2021.3.10