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- Title
Structure elucidation and synthesis of hydroxylated isatins from Streptomycetes.
- Authors
Shaaban, Khaled A.; Shaaban, Mohamed; Nair, Vimal; Schuhmann, Imelda; Win, Hnin Yu; Lei, Lei; Dittrich, Birger; Helmke, Elisabeth; Schüffler, Anja; Laatsch, Hartmut
- Abstract
Chemical investigation of terrestrial and marine streptomycete isolates led to the identification of two new natural pigments, namely, 6-hydroxyisatin ( 3) and 6-hydroxy-5-methoxyisatin ( 4). Additionally, the strains delivered numerous known compounds, among them N β-acetyltryptamine, N-acetyltyramine, phenylacetamide, N-(2-phenethyl)acetamide, 1-acetyl- β-carboline, tyrosol, 2′-deoxyadenosine, 2′-deoxythymidine, anthranilic acid, 2′-deoxyuridine, indolyl-3-acetic acid, indolyl-3-carboxylic acid, and p-hydroxybenzoic acid. The isatin structures were deduced by NMR and mass studies and further confirmed by synthesis and by X-ray diffraction of the isomeric 5-hydroxy-6-methoxyisatin ( 5).
- Subjects
ISATIN; CHEMICAL synthesis; X-ray diffraction; HYDROXYBENZOIC acid; CHROMIC acid
- Publication
Zeitschrift für Naturforschung B: A Journal of Chemical Sciences, 2016, Vol 71, Issue 12, p1191
- ISSN
0932-0776
- Publication type
Article
- DOI
10.1515/znb-2016-0143