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- Title
P-95: Does pulse pressure influence the hypercoagulable state in nonvalvular atrial fibrillation?
- Authors
Li-Saw-Hee, Foo L.; Blann, Andrew D.; Lip, Gregory Y.H
- Abstract
Clinical trials suggest hypertension contributes to the increased stroke rate in chronic nonvalvular atrial fibrillation (NVAF). There is evidence that NVAF confers a hypercoagulable state and the degree of blood pressure (BP) does not seem to affect it. However, the influence of pulse pressure on the prothrombotic state in NVAF is unknown.90 NVAF patients (60 males, mean age 67) were recruited. BP and pulse pressures were analysed according to tertiles. Levels of von Willebrand factor (vWf IU/dL, a marker of endothelial dysfunction), and markers of thrombosis (fibrinogen g/L [Clauss method] and fibrin D-dimer, ng/ml) were analysed by ELISA. Results were compared with matched healthy controls in sinus rhythm.Levels of all 3 markers were elevated in NVAF patients when compared to controls in sinus rhythm (SR) (all P<0.05). There was no significant relationship between the markers studied and degree of systolic, diastolic BP (not shown) and mean BP analysed by tertiles. However, there was a significant relationship between fibrin D-dimer and the tertiles of pulse pressure (p=0.04). [P=NS (ANOVA) except D-dimer* (p=0.04, Kruskal-Wallis). Results are mean±SD except D-dimer (interquartile range).]Patients with AF had abnormal thrombogenesis (fibrin D-dimer, fibrinogen) and endothelial dysfunction (vWf) compared to controls in sinus rhythm. There was a significant relationship between fibrin D-dimer and pulse pressure (p=0.04) but not with mean, systolic and diastolic BP. (See Table)Am J Hypertens (2001) 14, 61A-61A; doi:S0895-7061(01)01634-X
- Publication
American Journal of Hypertension, 2001, Vol 14, p61A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(01)01634-X