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- Title
The type 1 equilibrative nucleoside transporter regulates anxiety-like behavior in mice.
- Authors
Chen, J.; Rinaldo, L.; Lim, S.-J.; Young, H.; Messing, R. O.; Choi, D.-S.
- Abstract
Activation of adenosine receptors in the brain reduces anxiety-like behavior in animals and humans. Because nucleoside transporters regulate adenosine levels, we used mice lacking the type 1 equilibrative nucleoside transporter (ENT1) to investigate whether ENT1 contributes to anxiety-like behavior. The ENT1 null mice spent more time in the center of an open field compared with wild-type littermates. In the elevated plus maze, ENT1 null mice entered more frequently into and spent more time exploring the open arms. The ENT1 null mice also spent more time exploring the light side of a light–dark box compared with wild-type mice. Microinjection of an ENT1-specific antagonist, nitrobenzylthioinosine (nitrobenzylmercaptopurine riboside), into the amygdala of C57BL/6J mice reduced anxiety-like behavior in the open field and elevated plus maze. These findings show that amygdala ENT1 modulates anxiety-like behavior. The ENT1 may be a drug target for the treatment of anxiety disorders.
- Subjects
MICE behavior; ANXIETY; ANIMAL behavior; ADENOSINES; ANIMAL psychology
- Publication
Genes, Brain & Behavior, 2007, Vol 6, Issue 8, p776
- ISSN
1601-1848
- Publication type
Article
- DOI
10.1111/j.1601-183X.2007.00311.x