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- Title
铁死亡调控在骨质疏松症中的作用机制及中药干预 研究.
- Authors
庄文德; 郭浩华; 陈振; 钟诚; 张学来; 廖文庆; 郑鑫泽; 晋大祥; 谢炜星
- Abstract
As a common and highly hazardous metabolic disease, the incidence rate of osteoporosis (OP) is increasing year by year, but the anti-osteoporosis drugs are unfavorable for long-term use because they have high side effects. Ferroptosis is a novel form of cell death mainly characterized by an abnormal increase in reactive oxygen species (ROS), abnormal iron metabolism and lipid peroxidation accumulation. Recent studies have shown that ferroptosis is associated with the occurrence and progression of OP and disrupts bone homeostasis, causing the occurrence of OP, which has now become one of the newly hot research topics in the field of OP. As a cultural treasure of China, traditional Chinese medicine and its active ingredients in many studies not only have a regulatory effect on OP-related ferroptosis, but has unique advantages of the prevention and treatment of OP. Therefore, based on the summaries of the latest domestic and international studies on the mechanism of ferroptosis in OP and related TCM interventions, this paper aims to provide new research ideas for TCM prevention and treatment of OP from the perspective of ferroptosis.
- Publication
Chinese Journal of Osteoporosis, 2023, Vol 29, Issue 6, p890
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2023.06.020