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- Title
Interaction of BMI and respiratory status in obstructive sleep apnea, a cross-sectional COPD study.
- Authors
Hashiguchi, Mizuha Haraguchi; Chubachi, Shotaro; Yamasawa, Wakako; Otsuka, Kengo; Harada, Naoko; Miyao, Naoki; Nakamura, Hidetoshi; Asano, Koichiro; Yamaguchi, Kazuhiro; Fukunaga, Koichi
- Abstract
This cross-sectional study of 136 patients with chronic obstructive pulmonary disease (COPD) investigated the mechanism underlying overlap syndrome, defined as coexisting COPD and obstructive sleep apnea (OSA). OSA was defined as a respiratory event index (REI) ≥ 5 events/h, determined using type-3 portable monitors. The mean REI was 12.8 events/h. Most participants (60.1%) had mild OSA (REI: 5–15 events/h). The REI was positively correlated with forced expiratory volume in one second (%FEV1) (r = 0.33, p < 0.001), body mass index (BMI) (r = 0.24, p = 0.005), and fat-free mass index (r = 0.31, p = 0.005), and negatively correlated with residual volume divided by total lung capacity (r = −0.27, p = 0.003). Receiver-operating characteristic curve analysis revealed an optimal BMI cutoff of 21.96 kg/m2 for predicting moderate/severe OSA. A BMI ≥ 21.96 kg/m2 was associated with OSA among participants with %FEV1 ≥ 50%, but not those with %FEV1 < 50%. This study revealed an interaction between airflow limitation and hyperinflation, nutritional status, and OSA.
- Subjects
BODY mass index; SLEEP apnea syndromes; OBSTRUCTIVE lung diseases; LUNG volume measurements; MEDICAL statistics
- Publication
NPJ Primary Care Respiratory Medicine, 2023, Vol 33, Issue 1, p1
- ISSN
2055-1010
- Publication type
Article
- DOI
10.1038/s41533-023-00351-w