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- Title
Validation of the Persian version of COOP/WONCA functional health status charts in liver transplant candidates.
- Authors
Mahmoudi, Hilda; Jafari, Peyman; Ghaffaripour, Sina
- Abstract
Context--Health-related quality of life is a preferred outcome measure for patients with advanced liver disease. The functional health status charts developed by the Dartmouth Primary Care Cooperative Information Project (COOP)/World Organization of National Colleges, Academies and Academic Associations (WONCA) make up a generic instrument for assessing health-related quality of life. Objective--To translate and validate the Persian version of COOP/WONCA in liver transplant candidates and to assess the correlation of Child Pugh classification and Model of End Stage Liver Disease (MELD) score with quality of life. Setting--The Shiraz liver transplant center, the most active liver transplant center in the Middle East. Participants--Consecutive adult outpatients waiting for their first liver transplant who attended follow-up visits in the pretransplant clinic. Main Outcome Measures--Patients completed COOP/WONCA along with the Short Form (SF)-36. Data on the underlying cause of cirrhosis, Child-Pugh classification, and MELD scores were collected from medical records. Results--A Persian version of the COOP/WONCA was accepted by liver transplant candidates and showed adequate reliability and validity. Similar domains in COOP/WONCA charts and the SF-36 were highly correlated, indicating that construct validity of the COOP/WONCA in relation to the SF-36 was good (77% of correlations were as expected). Moreover, the exploratory factor analysis could not extract 2 different quality-of-life factors. These findings provide sufficient evidence to conclude that the Persian versions of COOP/WONCA charts and the SF-36 measure the same constructs of health-related quality of life and can be used interchangeably. Four of the 6 COOP/WONCA charts did not allow discrimination between groups of patients according to Child Pugh classification, indicating poor known group validity.
- Subjects
FUNCTIONAL assessment; ANALYSIS of variance; STATISTICAL correlation; DISCRIMINANT analysis; FACTOR analysis; HEALTH status indicators; HEALTH surveys; LIVER transplantation; RESEARCH methodology; QUESTIONNAIRES; RESEARCH; RESEARCH evaluation; STATISTICS; TRANSPLANTATION of organs, tissues, etc.; PILOT projects; DATA analysis; MULTITRAIT multimethod techniques; RESEARCH methodology evaluation; STATISTICAL models; DESCRIPTIVE statistics
- Publication
Progress in Transplantation, 2014, Vol 24, Issue 2, p126
- ISSN
1526-9248
- Publication type
Article
- DOI
10.7182/pit2014491