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- Title
Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells.
- Authors
Street, Jonathan M.; Birkhoff, Willem; Menzies, Robert I.; Webb, David J.; Bailey, Matthew A.; Dear, James W.
- Abstract
Non-technical summary Like most cells, those of the kidney release protein and RNA in structures called exosomes. It is possible that the contents of exosomes released into the urine from one part of the kidney can alter the function of downstream cells. We have used a cell model to test whether exosomes act as cell-to-cell messengers within the kidney. First, cells were exposed to a hormone that regulates the body's retention of water. This increased the levels of water channels within the cells and also within their exosomes. Next, these exosomes were placed onto a separate batch of cells, which responded by increasing their transport of water. This study shows that exosomes are a new mechanism for the transfer of physiological information within the kidney.
- Subjects
CELLS; URINE; KIDNEYS; HORMONES; BODY fluids
- Publication
Journal of Physiology, 2011, Vol 589, Issue 24, p6119
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2011.220277