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- Title
The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis.
- Authors
WENXIAN ZHENG; SHUISHENG ZHANG; SHENFENG ZHANG; LI MIN; YIHONG WANG; JIAN XIE; YONG HOU; XIUFANG TIAN; JIAN CHENG; KUN LIU; DEGUO XU; XINSHUANG YU; ZHEN LIU; YAJUAN LV; NING LIANG; JIANDONG ZHANG; FENGJUN LIU; YUAN TIAN
- Abstract
The aim of the present study was to evaluate the relationship between tumor necrosis factor‑α (TNF‑α) and the development of gastric cancer, and to investigate whether it can be used as a biological marker for gastric cancer. In the current study, a new meta‑analysis was performed to assess the association between TNF‑α gene polymorphisms and gastric cancer susceptibility. Subgroup analyses based on ethnicity, control population source and non‑cardia cancers were also conducted. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random‑effects model. TNF‑α 308 polymorphisms indicated a significant relationship with gastric cancer risk among a normal population [GA/AA vs. GG; 1.17 (1.10‑1.23)]. In analysis stratified by ethnicity, TNF‑α 238 displayed an association with gastric cancer risk in eastern populations [GA/AA vs. GG: 1.24 (1.02‑1.50)], but not in western populations [GA/AA vs. GG: 0.96 (0.79‑1.18)]. The overall ORs (95% CIs) for TNF‑α 857, TNF‑α 1031 and TNF‑α 863 were 1.13 (1.04‑1.24), 0.94 (0.85‑1.05) and 0.89 (0.78‑1.02), respectively, under dominant genetic model comparison. Among the above three SNPs, only TNF‑α 857 was robustly associated with gastric cancer inclination, and this association remained consistently robust when limited to non‑cardia gastric cancers [GA/AA vs. GG: 1.16 (1.03‑1.31)]. TNF‑α 308 and TNF‑α 857 genotypes were potential risk factors of statistical significance in gastric cancer, and TNF‑α 238 indicated to be significantly associated with gastric cancer risk only in eastern populations. TNF‑α 1031 and TNF‑α 863 were not significantly associated with gastric cancer risk.
- Subjects
TUMOR necrosis factors; GENETIC polymorphisms; CANCER; NECROSIS; CANCER susceptibility
- Publication
Biomedical Reports, 2017, Vol 7, Issue 2, p133
- ISSN
2049-9434
- Publication type
Article
- DOI
10.3892/br.2017.934