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- Title
Association of Inflammatory Metabolic Activity of Psoas Muscle and Acute Myocardial Infarction: A Preliminary Observational Study with 18 F-FDG PET/CT.
- Authors
Pahk, Kisoo; Kim, Eung Ju; Kwon, Hyun Woo; Joung, Chanmin; Seo, Hong Seog; Kim, Sungeun; Mielgo-Ayuso, Juan
- Abstract
Inflamed skeletal muscle promotes chronic inflammation in atherosclerotic plaques, thereby contributing to the increased risk of coronary artery disease (CAD). In this study, we evaluated the metabolic activity of psoas muscle, using 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), and its association with carotid artery inflammation and acute myocardial infarction (AMI). In total, 90 participants (32 AMI, 33 chronic stable angina (CSA), and 25 control) were enrolled in this prospective study. Metabolic activity of skeletal muscle (SM) was measured by using maximum standardized uptake value (SUVmax) of psoas muscle, and corresponding psoas muscle area (SM area) was also measured. Carotid artery inflammation was evaluated by using the target-to background ratio (TBR) of carotid artery. SM SUVmax was highest in AMI, intermediate in CSA, and lowest in control group. SM SUVmax was significantly correlated with carotid artery TBR and systemic inflammatory surrogate markers. Furthermore, SM SUVmax was independently associated with carotid artery TBR and showed better predictability than SM area for the prediction of AMI. Metabolic activity of psoas muscle assessed by 18F-FDG PET/CT was associated with coronary plaque vulnerability and synchronized with the carotid artery inflammation in the participants with CAD. Furthermore, it may also be useful to predict AMI.
- Subjects
PSOAS muscles; MYOCARDIAL infarction; COMPUTED tomography; POSITRON emission tomography computed tomography; CAROTID artery; ARTERITIS
- Publication
Diagnostics (2075-4418), 2021, Vol 11, Issue 3, p511
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics11030511