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- Title
No oncogenic mucosal human papillomaviruses in erosive vulval lichen planus.
- Authors
Kirtschig, G.; Brink, A. A. T. P.; Scheper, R. J.; Jaspars, E. H.
- Abstract
The article focuses on oncogenic mucosal human papillomaviruses in erosive vulval lichen planus. Erosive vulval lichen planus (LP) is a rare, difficult-to-treat inflammatory disease of unknown aetiology. One hypothesis is that a hypersensitivity reaction to a yet unidentified (intraepidermal) antigen may play a role. CD8+ lesional T cells are shown to be more cytotoxic against autologous lesional keratinocytes than clones isolated from nonlesional T-cell lines; the possible antigen may be associated with major histocompatibility complex class I on lesional keratinocytes. The absence of high-risk HPV in erosive vulval LP may also indicate that these HPV types play no role in causing malignancies in this form of LP.
- Subjects
PAPILLOMAVIRUSES; LICHEN planus; KERATINOCYTES; MAJOR histocompatibility complex; T cells; CELL lines; ETIOLOGY of diseases
- Publication
British Journal of Dermatology, 2005, Vol 152, Issue 6, p1367
- ISSN
0007-0963
- Publication type
Letter
- DOI
10.1111/j.1365-2133.2005.06601.x