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- Title
Effects of Selective Cyclooxygenase-2 Inhibitor and Non-Selective NSAIDs on Helicobacter pylori -Induced Gastritis in Mongolian Gerbils.
- Authors
Bhang, Choon Sang; Lee, Hak Sung; Kim, Sung Soo; Song, Ho Jin; Sung, Yong Jick; Kim, Jin Il; Chung, In Sik; Sun, Hee Sik; Park, Doo Ho; Lee, Youn Soo
- Abstract
Abstract Background. It is still a point of controversy whether Helicobacter pylori -infected patients are more likely to develop mucosal damage while taking NSADIs. Selective cyclooxygenase (COX-2) inhibitors may be associated with less severe gastric mucosal damage than conventional NSAIDs, but this association is undefined in H. pylori -induced gastritis. The aim of this study was to evaluate the effects of selective COX-2 and nonselective NSAIDs on H. pylori -induced gastritis. Methods. After intragastric administration of indomethacin, NS-398 or vehicle alone, once daily for 5 days in H. pylori- infected and uninfected Mongolian gerbils, we evaluated gastric mucosal damage, inflammatory cell infiltration and prostaglandin E2 (PGE2 ) concentration. We investigated whether H. pylori infection induced the COX-2 expression. Results. In H. pylori- uninfected groups, the indomethacin-treated group showed the highest mucosal damage score and the lowest PGE2 concentration. There was no difference in mucosal damage scores and PGE2 concentration between NS-398 and vehicle-alone treated group. In H. pylori- infected groups, there was no difference in mucosal damage scores, irrespective of the type of drugs administered. The indomethacin-treated group showed the lowest PGE2 concentration, similar to that of the NS-398 and vehicle-alone treated groups, both without H. pylori infection. Gastric neutrophil and monocyte infiltration scores were higher in H. pylori- infected groups than in uninfected groups. However, there was no difference in these scores according to the type of drugs administered, within H. pylori- infected or uninfected groups. COX-2 protein expression was observed in H. pylori- infected Mongolian gerbils but not in uninfected ones. Conclusions. Our animal study showed that H. pylori infection induced COX-2 expression and increased prostaglandin concentration. Administration of NSAIDs decreased the...
- Subjects
HELICOBACTER pylori infections; NONSTEROIDAL anti-inflammatory agents; CYCLOOXYGENASE 2
- Publication
Helicobacter, 2002, Vol 7, Issue 1, p14
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1046/j.1523-5378.2002.00051.x