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Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.
Published in:
Biochemical Journal, 2015, v. 471, n. 2, p. 255, doi. 10.1042/BJ20150678
By:
- Tanzer, Maria C.;
- Tripaydonis, Anne;
- Webb, Andrew I.;
- Young, Samuel N.;
- Varghese, Leila N.;
- Hall, Cathrine;
- Alexander, Warren S.;
- Hildebrand, Joanne M.;
- Silke, John;
- Murphy, James M.
Publication type:
Article
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.
Published in:
Biochemical Journal, 2014, v. 457, n. 3, p. 369, doi. 10.1042/BJ20131270
By:
- MURPHY, James M.;
- LUCET, Isabelle S.;
- HILDEBRAND, Joanne M.;
- TANZER, Maria C.;
- YOUNG, Samuel N.;
- SHARMA, Pooja;
- LESSENE, Guillaume;
- ALEXANDER, Warren S.;
- BABON, Jeffrey J.;
- SILKE, John;
- CZABOTAR, Peter E.
Publication type:
Article
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22400-z
By:
- Garnish, Sarah E.;
- Meng, Yanxiang;
- Koide, Akiko;
- Sandow, Jarrod J.;
- Denbaum, Eric;
- Jacobsen, Annette V.;
- Yeung, Wayland;
- Samson, Andre L.;
- Horne, Christopher R.;
- Fitzgibbon, Cheree;
- Young, Samuel N.;
- Smith, Phoebe P. C.;
- Webb, Andrew I.;
- Petrie, Emma J.;
- Hildebrand, Joanne M.;
- Kannan, Natarajan;
- Czabotar, Peter E.;
- Koide, Shohei;
- Murphy, James M.
Publication type:
Article
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis.
Published in:
EMBO Journal, 2021, v. 40, n. 23, p. 1, doi. 10.15252/embj.2019103718
By:
- Liu, Zikou;
- Dagley, Laura F;
- Shield‐Artin, Kristy;
- Young, Samuel N;
- Bankovacki, Aleksandra;
- Wang, Xiangyi;
- Tang, Michelle;
- Howitt, Jason;
- Stafford, Che A;
- Nachbur, Ueli;
- Fitzgibbon, Cheree;
- Garnish, Sarah E;
- Webb, Andrew I;
- Komander, David;
- Murphy, James M;
- Hildebrand, Joanne M;
- Silke, John
Publication type:
Article
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42255-w
By:
- Meng, Yanxiang;
- Garnish, Sarah E.;
- Davies, Katherine A.;
- Black, Katrina A.;
- Leis, Andrew P.;
- Horne, Christopher R.;
- Hildebrand, Joanne M.;
- Hoblos, Hanadi;
- Fitzgibbon, Cheree;
- Young, Samuel N.;
- Dite, Toby;
- Dagley, Laura F.;
- Venkat, Aarya;
- Kannan, Natarajan;
- Koide, Akiko;
- Koide, Shohei;
- Glukhova, Alisa;
- Czabotar, Peter E.;
- Murphy, James M.
Publication type:
Article
Defining a Water-Soluble Formulation of Arachidonic Acid as a Novel Ferroptosis Inducer in Cancer Cells.
Published in:
Biomolecules (2218-273X), 2024, v. 14, n. 5, p. 555, doi. 10.3390/biom14050555
By:
- Day, Zoe I.;
- Mayfosh, Alyce J.;
- Baxter, Amy A.;
- Williams, Scott A.;
- Hildebrand, Joanne M.;
- Rau, Thomas F.;
- Poon, Ivan K. H.;
- Hulett, Mark D.
Publication type:
Article
The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of Disease.
Published in:
Biomolecules (2218-273X), 2021, v. 11, n. 6, p. 803, doi. 10.3390/biom11060803
By:
- Tovey Crutchfield, Emma C.;
- Garnish, Sarah E.;
- Hildebrand, Joanne M.
Publication type:
Article
Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09536-9
By:
- Murai, Shin;
- Yamaguchi, Yoshifumi;
- Shirasaki, Yoshitaka;
- Yamagishi, Mai;
- Shindo, Ryodai;
- Hildebrand, Joanne M.;
- Miura, Ryosuke;
- Nakabayashi, Osamu;
- Totsuka, Mamoru;
- Tomida, Taichiro;
- Adachi-Akahane, Satomi;
- Uemura, Sotaro;
- Silke, John;
- Yagita, Hideo;
- Miura, Masayuki;
- Nakano, Hiroyasu
Publication type:
Article
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs.
Published in:
Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-06985-6
By:
- Murai, Shin;
- Yamaguchi, Yoshifumi;
- Shirasaki, Yoshitaka;
- Yamagishi, Mai;
- Shindo, Ryodai;
- Hildebrand, Joanne M.;
- Miura, Ryosuke;
- Nakabayashi, Osamu;
- Totsuka, Mamoru;
- Tomida, Taichiro;
- Adachi-Akahane, Satomi;
- Uemura, Sotaro;
- Silke, John;
- Yagita, Hideo;
- Miura, Masayuki;
- Nakano, Hiroyasu
Publication type:
Article
Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions.
Published in:
Immunological Reviews, 2011, v. 244, n. 1, p. 55, doi. 10.1111/j.1600-065X.2011.01055.x
By:
- Hildebrand, Joanne M.;
- Yi, Zuoan;
- Buchta, Claire M.;
- Poovassery, Jayakumar;
- Stunz, Laura L.;
- Bishop, Gail A.
Publication type:
Article
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation.
Published in:
Biochemical Journal, 2024, v. 481, n. 17, p. 1125, doi. 10.1042/BCJ20240255
By:
- Garnish, Sarah E.;
- Horne, Christopher R.;
- Yanxiang Meng;
- Young, Samuel N.;
- Jacobsen, Annette V.;
- Hildebrand, Joanne M.;
- Murphy, James M.
Publication type:
Article
A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes.
Published in:
Cell Death & Disease, 2021, v. 12, n. 4, p. 1, doi. 10.1038/s41419-021-03636-5
By:
- Hildebrand, Joanne M.;
- Lo, Bernice;
- Tomei, Sara;
- Mattei, Valentina;
- Young, Samuel N.;
- Fitzgibbon, Cheree;
- Murphy, James M.;
- Fadda, Abeer
Publication type:
Article
The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis.
Published in:
Cell Death & Disease, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41419-021-03418-z
By:
- Moujalled, Diane;
- Gangatirkar, Pradnya;
- Kauppi, Maria;
- Corbin, Jason;
- Lebois, Marion;
- Murphy, James M.;
- Lalaoui, Najoua;
- Hildebrand, Joanne M.;
- Silke, John;
- Alexander, Warren S.;
- Josefsson, Emma C.
Publication type:
Article
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.
Published in:
Science Signaling, 2021, v. 14, n. 668, p. 1, doi. 10.1126/scisignal.abc6178
By:
- Samson, André L.;
- Garnish, Sarah E.;
- Hildebrand, Joanne M.;
- Murphy, James M.
Publication type:
Article
Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway.
Published in:
Biochemical Society Transactions, 2022, v. 50, n. 1, p. 529, doi. 10.1042/BST20210517
By:
- Garnish, Sarah E.;
- Hildebrand, Joanne M.
Publication type:
Article
Is SIRT2 required for necroptosis?
Published in:
Nature, 2014, v. 506, n. 7489, p. E4, doi. 10.1038/nature13024
By:
- Newton, Kim;
- Hildebrand, Joanne M.;
- Shen, Zhirong;
- Rodriguez, Diego;
- Alvarez-Diaz, Silvia;
- Petersen, Sean;
- Shah, Saumil;
- Dugger, Debra L.;
- Huang, Chunzi;
- Auwerx, Johan;
- Vandenabeele, Peter;
- Green, Douglas R.;
- Ashkenazi, Avi;
- Dixit, Vishva M.;
- Kaiser, William J.;
- Strasser, Andreas;
- Degterev, Alexei;
- Silke, John
Publication type:
Article
Add necroptosis to your asthma action plan.
Published in:
Immunology & Cell Biology, 2021, v. 99, n. 8, p. 800, doi. 10.1111/imcb.12489
By:
- Garnish, Sarah E;
- Tovey Crutchfield, Emma C;
- Murphy, James M;
- Hildebrand, Joanne M
Publication type:
Article
Synaptic Zn<sup>2</sup><sup>+</sup> and febrile seizure susceptibility.
Published in:
2017
By:
- Reid, Christopher A;
- Hildebrand, Michael S;
- Mullen, Saul A;
- Hildebrand, Joanne M;
- Berkovic, Samuel F;
- Petrou, Steven
Publication type:
journal article
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04714-7
By:
- Petrie, Emma J.;
- Sandow, Jarrod J.;
- Jacobsen, Annette V.;
- Smith, Brian J.;
- Griffin, Michael D. W.;
- Lucet, Isabelle S.;
- Weiwen Dai;
- Young, Samuel N.;
- Tanzer, Maria C.;
- Wardak, Ahmad;
- Lung-Yu Liang;
- Cowan, Angus D.;
- Hildebrand, Joanne M.;
- Kersten, Wilhelmus J. A.;
- Lessene, Guillaume;
- Silke, John;
- Czabotar, Peter E.;
- Webb, Andrew I.;
- Murphy, James M.
Publication type:
Article
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
Published in:
Immunology & Cell Biology, 2017, v. 95, n. 2, p. 152, doi. 10.1038/icb.2016.125
By:
- Petrie, Emma J;
- Hildebrand, Joanne M;
- Murphy, James M
Publication type:
Article
A complex relationship between TRAF3 and non-canonical NF-κB2 activation in B lymphocytes.
Published in:
Frontiers in Immunology, 2013, v. 4, p. 1, doi. 10.3389/fimmu.2013.00477
By:
- Lin, Wai W.;
- Hildebrand, Joanne M.;
- Bishop, Gail A.
Publication type:
Article
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16887-1
By:
- Samson, Andre L.;
- Zhang, Ying;
- Geoghegan, Niall D.;
- Gavin, Xavier J.;
- Davies, Katherine A.;
- Mlodzianoski, Michael J.;
- Whitehead, Lachlan W.;
- Frank, Daniel;
- Garnish, Sarah E.;
- Fitzgibbon, Cheree;
- Hempel, Anne;
- Young, Samuel N.;
- Jacobsen, Annette V.;
- Cawthorne, Wayne;
- Petrie, Emma J.;
- Faux, Maree C.;
- Shield-Artin, Kristy;
- Lalaoui, Najoua;
- Hildebrand, Joanne M.;
- Silke, John
Publication type:
Article
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16819-z
By:
- Hildebrand, Joanne M.;
- Kauppi, Maria;
- Majewski, Ian J.;
- Liu, Zikou;
- Cox, Allison J.;
- Miyake, Sanae;
- Petrie, Emma J.;
- Silk, Michael A.;
- Li, Zhixiu;
- Tanzer, Maria C.;
- Brumatti, Gabriela;
- Young, Samuel N.;
- Hall, Cathrine;
- Garnish, Sarah E.;
- Corbin, Jason;
- Stutz, Michael D.;
- Di Rago, Ladina;
- Gangatirkar, Pradnya;
- Josefsson, Emma C.;
- Rigbye, Kristin
Publication type:
Article

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