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- Title
CD49b/CD69-dependent generation of restingT helper cell memory.
- Authors
Hanazawa, Asami; Löhning, Max; Radbruch, Andreas; Koji Tokoyoda
- Abstract
In the absence of antigen, memory T helper (Th) cells are maintained in a resting state. Recently it has been shown that bone marrow (BM) is a major reservoir of resting mem ory Th cells. In a given immune response, less than 10% of the activated CD4 T cells are recruited to the pool of resting BM memory Th cells. Here we review recent evidence that CD69 and CD49b control homing of memoryTh cell precursors to the BM. During the effector phase of an immune response, about 10% of activated CD4T cells in the spleen express both CD69 and CD49b, and thus qualify as precursors of resting memoryTh cells of BM. Loss or blockade of CD69 and CD49b expression on CD4T cells impairs the gener ation of resting memoryTh cells in the BM. Moreover, in the absence of BM memoryTh cells in CD69-deficient mice, T-cell help for B cells is impaired, confirming the central role of BM memoryTh cells in the maintenance of immunological memory.
- Subjects
IMMUNE response; BONE marrow; T cells; IMMUNOLOGIC memory; IMMUNE system
- Publication
Frontiers in Immunology, 2013, Vol 4, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2013.00183