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- Title
Cholinesterase Inhibiting Terpenoid from Albizia kalkora.
- Authors
Afzal, Muhammad; Ahmed, Ejaz; Sharif, Ahsan
- Abstract
Summary: Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT -IR, 1Dand 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer's disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3± 0.02, AChE and 19.0±0.03, BChE while galanthamine as a positive control (0.5 ± 0.05, AChE and 8.5±0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.
- Subjects
ACETYLCHOLINESTERASE; ALBIZIA; ALZHEIMER'S disease; BIOACTIVE compounds; MASS spectrometry; GALANTHAMINE
- Publication
Journal of the Chemical Society of Pakistan, 2023, Vol 45, Issue 1, p25
- ISSN
0253-5106
- Publication type
Article
- DOI
10.52568/001194/jcsp/45.01.2023