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- Title
Crystal Structures, Stability, and Solubility Evaluation of a 2:1 Diosgenin–Piperazine Cocrystal.
- Authors
Gong, Ningbo; Yu, Hongmei; Wang, Ying; Xing, Cheng; Hu, Kun; Du, Guanhua; Lu, Yang
- Abstract
A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized. The solid form was prepared by liquid assisted grinding, slurry and crystallization methods. The cocrystal was characterized by powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and structure determined by single crystal X-ray diffraction, the hydrogen bonds formed into fish bone structure along the [010] direction and all the molecules packed into 3D layer structure along a axis. After formation of cocrystal, the solubility of diosgenin was improved, and the solubility value in 0.2% SDS solution was approximately 1.5 times as large as that of the parent material.
- Subjects
CRYSTAL structure; FOURIER transform infrared spectroscopy; X-ray powder diffraction; DIOSGENIN; THERMOGRAVIMETRY
- Publication
Natural Products & Bioprospecting, 2020, Vol 10, Issue 4, p261
- ISSN
2192-2209
- Publication type
Article
- DOI
10.1007/s13659-020-00256-y