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- Title
Synthesis and Cytotoxicity Evaluation of Tropinone Derivatives.
- Authors
Yin, Xiu-Juan; Geng, Chang-An; Chen, Xing-Long; Sun, Chang-Li; Yang, Tong-Hua; Li, Tian-Ze; Zhou, Jun; Zhang, Xue-Mei; Chen, Ji-Jun
- Abstract
Sixteen tropinone derivatives were prepared, and their antitumor activities against five human cancer cells (HL-60, A-549, SMMC-7721, MCF-7 and SW480) were evaluated with MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy methoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium] assay. Most of the derivatives exhibited better activities compared with tropinone at the concentration of 40 μM. Particularly, derivative 6 showed significant activities with IC values of 3.39, 13.59, 6.65, 13.09 and 12.38 μM respectively against HL-60, A-549, SMMC-7721, MCF-7 and SW480 cells, which suggested more potent activities than that of cis-dichlorodiamineplatinum (DDP). Graphical Abstract:
- Subjects
CELL-mediated cytotoxicity; TROPINONES; METABOLITE synthesis; ANTINEOPLASTIC agents; CHEMICAL derivatives
- Publication
Natural Products & Bioprospecting, 2017, Vol 7, Issue 2, p215
- ISSN
2192-2209
- Publication type
Article
- DOI
10.1007/s13659-017-0124-z