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- Title
Pro-apoptotic Effects of OSNQ on Human Colon Cancer SW480 Cells.
- Authors
Yu ZHANG; Jiaru WANG; Yuchao FENG; Yi ZHANG; Wanting XU; Tong ZHANG; Shinong WANG; Hui XUE; Cheng LU; Wenzhong WANG; Meng NI; Hongxing WANG; Yinghua LUO; Chenghao JIN
- Abstract
[Objectives] The aim was to elucidate the pro-apoptosis mechanism of naphthoquinone derivative 2-octyl sulfoxide-1, 4-naphthoquinone(OSNQ) on human colon cancer SW480 cells. [Methods]The cytotoxic effect of OSNQ on colon cancer SW480 cells was detected by MTT colorimetry. The pro-apoptotic effect of OSNQ on human colon cancer SW480 cells was detected by Annexin V-FITC/PI double staining. The changes in expression of apoptosis-related proteins were detected by Western blot. [Results]The results of MTT assay showed that OSNQ had a significant cytotoxic effect on colon cancer SW480 cells. The results of Western blot showed that OSNQ induced the apoptosis in colon cancer SW480 cells through promoting the expression of pro-apoptotic caspase-3 and inhibiting the expression of apoptosis-inhibiting protein Bcl-2. [Conclusions] OSNQ has a significant cytotoxic effect on colon cancer SW480 cells, and it induces the apoptosis of colon cancer SW480 cells by AKT signaling pathway.
- Subjects
COLON cancer; CANCER cells; APOPTOSIS; NAPHTHOQUINONE; CELLULAR signal transduction
- Publication
Medicinal Plant, 2018, Vol 9, Issue 6, p46
- ISSN
2152-3924
- Publication type
Article
- DOI
10.19600/j.cnki.issn2152-3924.2018.06.012