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- Title
Mechanism of ligand binding - PDZ domain taken as example.
- Authors
Dułak, Dawid; Banach, Mateusz; Wiśniowski, Zdzisław; Konieczny, Leszek; Roterman, Irena
- Abstract
The mechanism of specific ligand binding by proteins is discussed using the PDZ domain complexing the pentapeptide. This process is critical for clustering the membrane ion channel. The traditional model based on the Beta-sheet extension by complexed pentapeptide is interpreted as a hydrophobic core extension supported by additional Beta-strand generated by complexed pentapeptide. The explanation is based on the fuzzy oil drop model applied to the crystal structure of PDZ-pentapeptide.
- Subjects
LIGAND binding (Biochemistry); PDZ proteins; MATHEMATICAL domains; CRYSTAL structure; ION channels
- Publication
Bio-Algorithms & Med-Systems, 2017, Vol 13, Issue 4, p175
- ISSN
1895-9091
- Publication type
Article
- DOI
10.1515/bams-2017-0022