We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder.
- Authors
Asherson, P.; Mant, R.; Williams, N.; Cardno, A.; Jones, L.; Murphy, K.; Collier, D.A.; Nanko, S.; Craddock, N.; Morris, S.; Muir, W.; Blackwood, B.; McGuffin, P.; Owen, M.J.
- Abstract
There are several lines of evidence which suggest that chromosome 4p may contain a major susceptibility locus for the functional psychoses. We previously reported a family (family 50) with cases of schizophrenia and schizoaffective disorder which gave maximum Iod scores of 1.96 and 1.84 respectively with the markers D4S403 and a microsatellite near to DRD5 (DRD5M). More recently Blackwood and co-workers described a family segregating bipolar and unipolar affective disorders which gives a maximum Iod score of 4.1 with the marker D4S394, which lies 10 cM from D4S403. They obtained a combined maximum Iod of 3.3 in their total sample of 12 bipolar families and found significant evidence of heterogeneity (χ² = 18.8, df=2, P=0.00008). Here we report the results of a linkage study of chromosome 4p markers in a sample of 24 multiply affected families with schizophrenia and related disorders. We obtained an overall maximum Iod of 1.12 with D4S403 under both dominant and recessive modes of transmission, with no statistical support for heterogeneity within our sample. Examination of family by family data shows that only family 50 appears to show linkage at this locus. However, a discrepancy exists since our study examined families fulfilling criteria for a linkage study of schizophrenia while Blackwood et al examined families included in a genetic linkage study of bipolar disorder. This may be explained by the clinical features displayed by members of family 50, which show that all the affected members have some affective symptoms. It is therefore possible that a broad phenotype including unipolar depression, bipolar disorder, schizoaffective disorder and schizophrenia when accompanied by significant affective symptoms can result from mutations within a gene in this region. The dopamine D5 receptor gene lies within the region identified by the linkage studies and is therefore a major candidate for the putative disease gene. In family 50 we have looked for...
- Subjects
DOPAMINE receptors; SCHIZOPHRENIA; BIPOLAR disorder; BIOMARKERS; CHROMOSOMES
- Publication
Molecular Psychiatry, 1998, Vol 3, Issue 4, p310
- ISSN
1359-4184
- Publication type
Article
- DOI
10.1038/sj.mp.4000399