We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Clinical Significance of Uric Acid and Complement Activation in the Progression of IgA Nephropathy.
- Authors
Caliskan, Yasar; Ozluk, Yasemin; Celik, Dilara; Oztop, Nida; Aksoy, Aysun; Ucar, Ayse Serra; Yazici, Halil; Kilicaslan, Isin; Sever, Mehmet Sukru
- Abstract
Background/Aims: The aim of this study is to investigate the utility of clinical [age, gender, mean arterial pressure (MAP)] and laboratory parameters [eGFR, hemoglobin (Hgb), serum levels of creatinine, uric acid, albumin, proteinuria, hematuria] and also histopathological lesions (Oxford classification parameters, crescents, intensity and pattern of staining for C3, C1Q, IgA, IgG, IgM) as progression markers in patients with IgA Nephropathy (IgAN). Methods: A total of 111 IgAN patients with a follow-up period >1 year or who reached kidney failure [GFR category G5 chronic kidney disease (CKD)] <1 year were investigated. Primary endpoint was the development of kidney failure or eGFR decline ≥50% from the baseline. Kaplan-Meier and Cox proportional hazards analyses were performed. Results: Mean follow-up period was 33±29 months. Thirty-seven (33.3%) patients progressed to kidney failure and 4 (3.6%) patients developed eGFR decline ≥50% from the baseline after a median of 23 and 65 months, respectively. In multivariate Cox regression analysis, baseline levels of Hgb (HR:0.782, 95% CI 0.559-0.973, p=0.037), serum uric acid (HR:1.293, 95% CI 1.023-1.621, p=0.046), eGFR (HR:0.966, 95% CI 0.947-0.984, p=0.004) and intensity of C3 staining (HR:1.550, 95% CI 1.198-1.976, p=0.049) predicted primary endpoint. Serum uric acid level was associated independently with T score (β=0.303, p=0.005) in patients with eGFR>30 ml/min/m2. Conclusions: Hyperuricemia and the deposition of C3 are independent risk factors for IgAN progression.
- Subjects
IGA glomerulonephritis; URIC acid; COMPLEMENT activation; TUMOR lysis syndrome; KIDNEY failure; CHRONIC kidney failure
- Publication
Kidney & Blood Pressure Research, 2024, Vol 41, Issue 2, p148
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000443415