We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
NO Synthase in the Liver: Prospects of in vivo Gene Transfer.
- Authors
Fevery, J.; Roskams, T.; Van de Casteele, M.; Omasta, A.; Janssens, S.; Desmet, V.; Nevens, F.
- Abstract
Portal hypertension is a major complication of cirrhosis, portal vein thrombosis, presinusoidal liver diseases such as schistosomiasis and postsinusoidal disorders such as veno-occlusive disease or Budd-Chiari syndrome. The elevated pressure results from enhanced resistance in the portal venous system and from augmented influx of blood due to splanchnic vasodilatation and hypervolemia [1]. The enhanced intrahepatic resistance in cirrhotic livers is partly due to fibrosis [2] and partly to active vasoconstriction, since Bathal and Grossman [3] could demonstrate in the isolated perfused cirrhotic rat liver that the increased portal vascular resistance could be decreased by medication.
- Subjects
NITRIC oxide; GENETIC transformation; NUCLEIC acids; GENETIC recombination; PORTAL hypertension; CIRRHOSIS of the liver
- Publication
Digestion, 1998, Vol 59, p58
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000051424