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- Title
HOXA11 is another monogenic cause of congenital anomalies of the kidney and urinary tract.
- Authors
Saygili, Seha; Caliskan, Salim; Ozaltin, Fatih
- Abstract
The authors convey their thoughts on a study review about the genetic basis of congenital anomalies of the kidney and urinary tract (CAKUT). Topics mentioned include the role of Hox genes in various developmental stages of the human embryo, the association of homozygous or heterozygous variants in Homeobox A11 (HOXA11) with syndromic and/or isolated CAKUT phenotypes, and the molecular pathogenesis of HOXA11-related disease in humans with CAKUT.
- Subjects
KIDNEY physiology; URINARY organ physiology; KIDNEY diseases; DNA-binding proteins; URINARY organ diseases
- Publication
Pediatric Nephrology, 2023, Vol 38, Issue 3, p933
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-022-05756-2