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- Title
High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints.
- Authors
Jansen, Anouk M. E.; ter Heine, Rob; Verweij, Paul E.; Brüggemann, Roger J. M.
- Abstract
Isavuconazole exposure–response relationships have been studied with a focus on total rather than unbound exposure, assuming a constant unbound fraction of 1%. We observed a median (range) unbound fraction of 1.59% (0.42–5.30%) in patients. This highly variable protein binding asks for re-evaluation of current pharmacokinetic and pharmacodynamic targets for isavuconazole.
- Subjects
PHARMACOKINETICS; FRACTIONS; PROTEIN binding
- Publication
Clinical Pharmacokinetics, 2023, Vol 62, Issue 12, p1695
- ISSN
0312-5963
- Publication type
Article
- DOI
10.1007/s40262-023-01311-w