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- Title
Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults.
- Authors
Sapkota, Shraddha; Wiebe, Sandra A.; Small, Brent J.; Dixon, Roger A.
- Abstract
<bold>Objectives: </bold>Recent research has linked psychological (personality) factors and specific genetic risk polymorphisms to performance on neurocognitive phenotypes. We examined whether episodic or semantic memory performance is associated with (a) three personality traits (i.e. neuroticism, extraversion, and openness to experience), (b) two neurodegenerative-related polymorphisms (i.e. Apolipoprotein E (APOE; rs7412; rs429358), Clusterin (CLU; rs11136000)), and (c) cross-domain risk interactions (magnification effects).<bold>Methods: </bold>Linear growth models were examined to test independent associations between personality traits and declarative memory performance, and potential interaction effects with APOE and CLU genetic risk. Normal older adults (n = 282) with personality and genetic data from the Victoria Longitudinal Study were included at baseline and for up to 14 years of follow-up.<bold>Results: </bold>First, we observed that higher openness to experience levels were associated with better episodic and semantic memory. Second, three significant gene × personality interactions were associated with poorer memory performance at baseline. These synergistic effects are: (a) APOE allelic risk (ε4+) carriers with lower openness to experience levels, (b) CLU (no risk: T/T) homozygotes with higher extraversion levels, and (c) CLU (no risk: T/T) homozygotes with lower neuroticism levels.<bold>Conclusions: </bold>Specific neurodegenerative-related genetic polymorphisms (i.e. APOE and CLU) moderate and magnify the risk contributed by selected personality trait levels (i.e. openness to experience, extraversion) on declarative memory performance in non-demented aging. Future research could target interactions of other personality traits and genetic polymorphisms in different clinical populations to predict other neurocognitive deficits or transitions to cognitive impairment and dementia.
- Subjects
GENETIC polymorphisms; APOLIPOPROTEIN E; CLUSTERIN; OLDER people; NEURODEGENERATION; AGING; APOLIPOPROTEINS; GLYCOPROTEINS; LONGITUDINAL method; NEUROPSYCHOLOGICAL tests; MEMORY; PERSONALITY; REGRESSION analysis; RESEARCH funding; ANXIETY disorders
- Publication
International Journal of Geriatric Psychiatry, 2016, Vol 31, Issue 5, p502
- ISSN
0885-6230
- Publication type
journal article
- DOI
10.1002/gps.4355