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- Title
THE USE OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS FOR DEPRESSION AND PSYCHOSIS COMPLICATING DEMENTIA.
- Authors
Burke, William J.; Dewan, Vijay; Wengel, Steven P.; Roccaforte, William H.; Nadolny, Grace C.; Folks, David G.
- Abstract
This retrospective chart review examines the impact of selective serotonin reuptake inhibitors on 20 patients with both depression and psychosis complicating dementia of the Alzheimer type (DAT) and other dementias. Fifteen of the 20 patients had moderate to marked improvement in depressive and psychotic symptoms. Eleven of 12 patients with DAT had moderate to marked improvement compared to only four of eight patients with dementia from other causes. The drugs were effective in diminishing or eliminating psychotic symptoms in six patients who had previously not responded to a trial of a neuroleptic. The selective serotonin reuptake inhibitors may have an important role to play in patients with DAT who have coexisting depression and psychosis. These drugs are very well tolerated and may have a place as first-line agents in non-emergent settings where a clinician might otherwise think of instituting a neuroleptic or as a second-line agent when a neuroleptic has proven ineffective. © 1997 John Wiley & Sons, Ltd.
- Subjects
SEROTONIN uptake inhibitors; DEMENTIA; ALZHEIMER'S disease; ANTIPSYCHOTIC agents; PSYCHOSES
- Publication
International Journal of Geriatric Psychiatry, 1997, Vol 12, Issue 5, p519
- ISSN
0885-6230
- Publication type
Article
- DOI
10.1002/(SICI)1099-1166(199705)12:5<519::AID-GPS534>3.0.CO;2-Q