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- Title
Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation.
- Authors
Krüger, Bernd; Yin, Na; Zhang, Nan; Yadav, Anju; Coward, William; Lal, Girdhari; Zang, Weiping; S. Heeger, Peter; Bromberg, Jonathan S.; Murphy, Barbara; Schröppel, Bernd
- Abstract
Although islet transplantation is an effective treatment for Type 1 diabetes, primary engraftment failure contributes to suboptimal outcomes. We tested the hypothesis that islet isolation and transplantation activate innate immunity through TLR expressed on islets. Murine islets constitutively express TLR2 and TLR4, and TLR activation with peptidoglycan or LPS upregulates islet production of cytokines and chemokines. Following transplantation into streptozotocin-induced diabetic, syngeneic mice, islets exposed to LPS or peptidoglycan had primary graft failure with intra- and peri-islet mononuclear cell inflammation. The use of knockout mice showed that recipient CD8
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 10, p2914
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201040601