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- Title
The effect of an anti-inflammatory in comparison with a low caloric diet on physical and mental health in overweight and obese women with knee osteoarthritis: a randomized clinical trial.
- Authors
Dolatkhah, Neda; Toopchizadeh, Vahideh; Barmaki, Sahel; Salekzamani, Yagoub; Najjari, Afsaneh; Farshbaf-Khalili, Azizeh; Dolati, Sanam
- Abstract
Purpose: To evaluate the effect of an anti-inflammatory compared to a low-calorie diet on the physical and mental health of patients with knee OA. Methods: In this randomized parallel clinical trial, participants were selected among overweight and obese women aged 40 years or older with mild to moderate OA. Sixty women with a ratio of 1:1 were randomly assigned to receive either low-calorie or anti-inflammatory accompanied by a low-calorie diet for two months. The dietary intake and weight of participants were measured. Study variables were assessed using the Western Ontario and McMaster Index (WOMAC), visual analog pain scale (VAS), Beck Depression Inventory (BDI-II), Beck Anxiety Inventory (BAI-I), and the Short Form 36 Health Survey Questionnaire (SF-36) to indicate the quality of life (QoL). Results: There was no statistically significant difference between the two groups in demographic and baseline variables except for the emotional well-being subscale of QoL. There was significant difference in anti-inflammatory compared to low-calorie diet in terms of weight (MD (95% CI): − 4.02 kg (− 6.77 to − 1.28); p = 0.005), VAS (MD (95% CI): − 0.97 (− 1.53 to − 0.41); p = 0.001), WOMAC-total score (MD (95% CI): − 9.91 (− 15.05 to − 4.78); p < 0.001), WOMAC-pain subscale (MD (95% CI): − 3.30 (− 5.30 to − 1.29); p = 0.002), WOMAC-physical function (MD(95% CI): − 5.48 (− 9.41 to − 1.53); p = 0.007), depression (p = 0.003), anxiety (p = 0.011), QoL-physical functioning (0.041), and QoL-pain (0.010) after the intervention. Conclusion: An anti-inflammatory accompanied by a low-calorie diet resulted in greater weight loss and greater improvement in pain intensity, functional status, depression, anxiety, and some dimension of QoL in overweight and obese women with knee OA compared to the low-calorie diet. Trial registration number and date of registration: IRCT201610220030424N2; 2018-04-23.
- Subjects
PREVENTION of mental depression; COMPETENCY assessment (Law); ANXIETY prevention; OBESITY treatment; OBESITY &; psychology; KNEE osteoarthritis; BODY weight; CONFIDENCE intervals; PAIN measurement; ANTI-inflammatory agents; FOOD consumption; FUNCTIONAL status; REDUCING diets; HEALTH status indicators; VISUAL analog scale; HEALTH surveys; TREATMENT effectiveness; RANDOMIZED controlled trials; COMPARATIVE studies; PSYCHOLOGICAL tests; PSYCHOLOGY of women; DESCRIPTIVE statistics; RESEARCH funding; QUESTIONNAIRES; QUALITY of life; WEIGHT loss; STATISTICAL sampling; EVALUATION
- Publication
European Journal of Nutrition, 2023, Vol 62, Issue 2, p659
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-022-03017-4