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- Title
An efficient and facile synthesis of novel substituted pyrimidine derivatives: 4-amino-5-carbonitrile-2-nitroaminopyrimidine.
- Authors
Xia, Sheng; Yin, Shan; Tao, Shimin; Shi, Yanhui; Rong, Liangce; Wei, Xianyong; Zong, Zhimin
- Abstract
One-pot, multicomponent reaction for the synthesis of novel substituted pyrimidine derivatives: 4-amino-5-carbonitrile-2-nitroaminopyrimidine from aromatic aldehydes, 1-nitroguanidine, and malononitrile under ethanol is described. Because of containing many active functional groups, such as amino, cyan and nitro, these products are important intermediate of organic synthesis. The advantages of this procedure include the short reaction time, mild reaction conditions, and excellent yields.
- Subjects
PYRIMIDINE derivatives; ORGANIC synthesis; CHEMICAL reactions; AROMATIC aldehydes; NITROGUANIDINE; MALONONITRILE; FUNCTIONAL groups
- Publication
Research on Chemical Intermediates, 2012, Vol 38, Issue 9, p2435
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-012-0559-0