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- Title
No relations between breast cancer risk and fatty acids of erythrocyte membranes in postmenopausal women of the Malmö Diet Cancer cohort (Sweden).
- Authors
Wirfält, E.; Vessby, B.; Mattisson, I.; Gullberg, B.; Olsson, H.; Berglund, G.
- Abstract
To examine the fatty acid composition of erythrocyte membranes, in relation to obesity indexes and breast cancer risk. A nested casecontrol study. The Malmö Diet Cancer cohort, Sweden. Among women 50 y or older at baseline (n=12 803), incident breast cancer cases (n=237) were matched to controls (n=673) on age and screening date. DFA and EFA from fish and milk, and DFA and EFA linoleic acid, show significant positive associations. Relations are negative between indexes of obesity and ‘milk’ EFA, but positive between indexes of obesity and indexes of delta9- and delta6- desaturase enzyme activity. No significant relations were observed between EFA and breast cancer risk. Similar to other studies, dietary fish and milk fatty acids, and linoleic acid, are related to the corresponding EFA. Breast cancer risk was not significantly related to EFA in this study. However, the findings suggest positive relations between body mass index, body fat per cent and indexes of desaturase activity, and negative relations between central obesity and milk EFA. The Swedish Cancer Society, the Swedish Medical Research Council, the European Commission, the Swedish Dairy Association and the City of Malmö.
- Subjects
SWEDEN; BREAST cancer; CANCER in women; FATTY acids; ERYTHROCYTE membranes; NUTRITION; MEDICAL research; CANCER risk factors
- Publication
European Journal of Clinical Nutrition, 2004, Vol 58, Issue 5, p761
- ISSN
0954-3007
- Publication type
Article
- DOI
10.1038/sj.ejcn.1601874