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- Title
Timing of start of systemic treatment in patients with asymptomatic metastasized pancreatic cancer (TIMEPAN): a protocol of a multicenter prospective patient preference non-randomized trial.
- Authors
Augustinus, Simone; Broekman, Thijmen; Creemers, Geert-Jan; Daamen, Lois A.; van Dieren, Susan; de Groot, Jan-Willem B.; Cirkel, Geert A.; Homs, Marjolein Y. V.; van Laarhoven, Hanneke W. M.; van Leeuwen, Lobke; Los, Maartje; Luelmo, Saskia A. C.; van Oijen, Martijn G. H.; Spierings, Leontine E. A. M.; de Vos-Geelen, Judith; Besselink, Marc G.; Wilmink, Johanna W.
- Abstract
The article focuses on a multicenter prospective patient preference trial named "Timing of start of systemic treatment in patients with asymptomatic metastasized pancreatic cancer (TIMEPAN)." Topics include the lack of evidence on treatment initiation timing, the potential benefits and risks of immediate versus delayed systemic treatment, and the trial's methodology, including patient eligibility criteria and study design alteration due to recruitment challenges.
- Subjects
PANCREATIC tumors; RESEARCH; METASTASIS; MANN Whitney U Test; REGRESSION analysis; T-test (Statistics); QUESTIONNAIRES; CHI-squared test; DESCRIPTIVE statistics; KAPLAN-Meier estimator; QUALITY of life; LONGITUDINAL method; OVERALL survival; PROPORTIONAL hazards models
- Publication
Acta Oncologica, 2023, Vol 62, Issue 12, p1973
- ISSN
0284-186X
- Publication type
Letter to the Editor
- DOI
10.1080/0284186X.2023.2273898