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- Title
Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence.
- Authors
Gazon, Hélène; de Brogniez, Alix; Willems, Luc; Carpentier, Alexandre; Barez, Pierre-Yves; Hamaidia, Malik; Perike, Srikanth; Gillet, Nicolas
- Abstract
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy--tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly infected host. The virus then replicates by either one of two modes: (i) an infectious cycle by virus budding and infection of new targets and (ii) mitotic division of cells harboring an integrated provirus. HTLV-1 replication initiates a series of mechanisms in the host including antiviral immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to counteract these defense mechanisms allowing continuous persistence in humans.
- Subjects
HTLV-I; VIRAL replication; RETROVIRUS diseases; VIRION; DNA replication; RNA modification &; restriction; GENETICS
- Publication
Viruses (1999-4915), 2015, Vol 7, Issue 7, p3603
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v7072793