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- Title
Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis.
- Authors
Fouad, Tamer R; Abdelsameea, Eman; Elsabaawy, Maha; Ashraf Eljaky, M.; Zaki El-shenawy, Soha; Omar, Nabil
- Abstract
Cirrhotic patients with ascites are at high risk of developing spontaneous bacterial peritonitis (SBP). After exclusion of patients with acute kidney injury (AKI) or other infections, urinary neutrophil gelatinase-associated lipocalin (NGAL) levels were compared between two matched groups of Egyptian cirrhotic patients with ascites, mostly secondary to hepatitis C infection (98%). Group 1 had SBP (n = 41) and group 2 did not (n = 45). By univariate analysis, urinary-NGAL, high total bilirubin, serum creatinine, international normalised ratio and the Model of End-Stage Liver Disease (MELD) score and low platelet count were all significantly correlated with the presence of SBP, but only urinary-NGAL could independently predict development of SBP (P = 0.001). Urinary-NGAL at a cut-off value of 1225 pg/mL, showed a sensitivity of 95% and a specificity of 76%, and is therefore a most useful tool.
- Subjects
LIPOCALIN-2; PERITONITIS; KIDNEY injuries; HEPATITIS C; PLATELET count
- Publication
Tropical Doctor, 2019, Vol 49, Issue 3, p189
- ISSN
0049-4755
- Publication type
journal article
- DOI
10.1177/0049475519830265