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- Title
Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling "Pearling" States, and Terfenadine Loading/Release Studies.
- Authors
Botcha, Ajay Kumar; Dulla, Balakrishna; Reddy, E. Ramanjaneya; Chennubhotla, Keerthana S.; Kulkarni, Pushkar; Chandrasekar, Rajadurai; Rajadurai, Marina S.
- Abstract
"Sustained drug delivery systems" which are designed to accomplish long-lasting therapeutic effect are one of the challenging topics in the area of nanomedicine. We developed an innovative strategy to prepare nontoxic and polymer stabilized organic nanovesicles (diameter: 200 nm) from a novel bolaamphiphile, where two hydrogen bonding acetyl cytosine molecules connected to 4,4"-positions of the 2,6-bispyrazolylpyridine through two flexible octyne chains. The nanovesicles behave like biological membrane by spontaneously self-assembling into "pearl-like" chains and subsequently forming long nanotubes (diameter: 150 nm), which further develop into various types of network-junctions through self-organization. For drug loading and delivery applications, the nanovesicleswere externally protectedwith biocompatible poly(ethyleneglycol)-2000 to prevent them fromfusion and ensuing tube formation. Nontoxic nature of the nanovesicles was demonstrated by zebrafish teratogenicity assay. Biocompatible nanovesicles were loaded with "terfenadine" drug and successfully utilized to transport and release drug in sustained manner (up to 72 h) in zebrafish larvae, which is recognized as an emerging in vivo model system.
- Subjects
DRUG delivery systems; DRUG synthesis; VESICLES (Cytology); TERFENADINE; CONTROLLED release drugs; NANOMEDICINE; HYDROGEN bonding; TERATOGENICITY testing
- Publication
Journal of Nanotechnology, 2014, p1
- ISSN
1687-9503
- Publication type
Article
- DOI
10.1155/2014/369139