We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bioactivity-guided Isolation of TRAIL-Resistance-Overcoming Activity Compounds From the Leaves of Murraya exotica.
- Authors
Masami Ishibashi; Kritamorn Jitrangsri; Akiko Takaya; Yasumasa Hara; Sadhu, Samir K.; Ahmed, Firoj
- Abstract
Fractionation of the leaf extract from Murraya exotica led to the successful isolation of 12 compounds (1-12) with TRAIL-resistance-over coming activity. Xanthinosin (1), 11α, 13-dihydroxanthinin (2), 11β, 13-dihydroxanthinosin (3), 4α, 11α, 13-trihydroxanthuminol (4), desacetylxanthanol (5), and lasidiol p-methoxybenzoate (6) were sesquiterpenes isolated from this plant for the first time, and 3 was isolated from natural sources for the first time. Among them, compounds1 and 5 showed strong TRAIL-resistance-overcoming activity, but their mechanisms have already been revealed. Furthermore, dihydroxanthinin (2), 1, 5-dicaffeoylquinic acid (7), and (-) loliolide (8), which belong to different phytochemical groups, were investigated for their effects on increasing apoptosis induction to overcome TRAIL resistance using Western blot analysis. The results demonstrated that 2, 7, and 8 promoted TRAIL-induced apoptosis by increasing the expression of several proapoptotic markers, including cleaved caspases −3 and −8, and suppressing anti-apoptotic protein Bcl-2
- Subjects
PHYTOCHEMICALS; WESTERN immunoblotting; BCL-2 proteins; TRAIL protein; SESQUITERPENES
- Publication
Natural Product Communications, 2021, Vol 16, Issue 12, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X211065843