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- Title
Recombinant factor VIIa as a rescue therapy in severe haemoptysis in a patient with a Fontan circulation.
- Authors
Mason, Thomas W.; Retter, Andrew; Morgan, Gareth J.
- Abstract
We describe the successful use of recombinant factor VIIa (rFVIIa) in the control of massive haemoptysis in a 17-year-old patient with a Fontan circulation. The patient was intubated and ventilated in the ICU with deteriorating gas exchange. Conventional methods to control the haemoptysis were ineffective, and rFVIIa was successfully administered as a rescue therapy. rFVIIa is a powerful pro-thrombotic agent, which is only licensed in haemophiliacs with acquired inhibitors to anticoagulation. It has been used off-license in the treatment of massive haemorrhage, although a Cochrane review did not show any significant benefit; however, it may have a role as a rescue therapy where alternatives options have been exhausted after careful risk–benefit analysis.
- Subjects
BLOOD coagulation factor VII; HEMOPTYSIS; ADOLESCENT health; HOSPITAL admission &; discharge; INTENSIVE care units; PULMONARY gas exchange; THERAPEUTICS
- Publication
Cardiology in the Young, 2018, Vol 28, Issue 1, p144
- ISSN
1047-9511
- Publication type
journal article
- DOI
10.1017/S1047951117001007