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- Title
Low Prevalence of Chlamydia trachomatis Infection in Non-Urban Pregnant Women in Vellore, S. India.
- Authors
Vidwan, Navjyot K.; Regi, Annie; Steinhoff, Mark; Huppert, Jill S.; Staat, Mary Allen; Dodd, Caitlin; Nongrum, Rida; Anandan, Shalini; Verghese, Valsan
- Abstract
Objective: To determine the prevalence and risk factors for Chlamydia trachomatis (CT) infection in pregnant women and the rate of transmission of CT to infants. Methods: Pregnant women (⩾28 weeks gestation) in Vellore, South India were approached for enrollment from April 2009 to January 2010. After informed consent was obtained, women completed a socio-demographic, prenatal, and sexual history questionnaire. Endocervical samples collected at delivery were examined for CT by a rapid enzyme test and nucleic acid amplification test (NAAT). Neonatal nasopharyngeal and conjunctival swabs were collected for NAAT testing. Results: Overall, 1198 women were enrolled and 799 (67%) endocervical samples were collected at birth. Analyses were completed on 784 participants with available rapid and NAAT results. The mean age of women was 25.8 years (range 18- 39 yrs) and 22% (95% CI: 19.7-24.4%) were primigravida. All women enrolled were married; one reported > one sexual partner; and six reported prior STI. We found 71 positive rapid CT tests and 1/784 (0.1%; 95% CI: 0-0.38%) true positive CT infection using NAAT. Conclusions: To our knowledge, this is the largest study on CT prevalence amongst healthy pregnant mothers in southern India, and it documents a very low prevalence with NAAT. Many false positive results were noted using the rapid test. These data suggest that universal CT screening is not indicated in this population.
- Subjects
VELLORE (India); INDIA; CHLAMYDIA trachomatis; DISEASE prevalence; BACTERIAL diseases; DISEASE risk factors; INFECTIOUS disease transmission; PREGNANT women
- Publication
PLoS ONE, 2012, Vol 7, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0034794