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- Title
MicroRNA Expression Characterizes Oligometastasis(es).
- Authors
Lussier, Yves A.; Xing, H. Rosie; Salama, Joseph K.; Khodarev, Nikolai N.; Yong Huang; Qingbei Zhang; Khan, Sajid A.; Xinan Yang; Hasselle, Michael D.; Darga, Thomas E.; Malik, Renuka; Fan, Hanli; Perakis, Samantha; Filippo, Matthew; Corbin, Kimberly; Younghee Lee; Posner, Mitchell C.; Chmura, Steven J.; Hellman, Samuel; Weichselbaum, Ralph R.
- Abstract
Background: Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤5 cumulative metastasis(es), termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients may benefit from metastasis-directed local treatments. However, many patients who initially present with oligometastases progress to polymetastases. Predictors of progression could improve patient selection for metastasis-directed therapy. Methods: Here, we identified patterns of microRNA expression of tumor samples from oligometastatic patients treated with high-dose radiotherapy. Results: Patients who failed to develop polymetastases are characterized by unique prioritized features of a microRNA classifier that includes the microRNA-200 family. We created an oligometastatic-polymetastatic xenograft model in which the patient-derived microRNAs discriminated between the two metastatic outcomes. MicroRNA-200c enhancement in an oligometastatic cell line resulted in polymetastatic progression. Conclusions: These results demonstrate a biological basis for oligometastases and a potential for using microRNA expression to identify patients most likely to remain oligometastatic after metastasis-directed treatment.
- Subjects
MICRORNA; CANCER treatment; CANCER invasiveness; METASTASIS; PATHOLOGY; CANCER patients
- Publication
PLoS ONE, 2011, Vol 6, Issue 12, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0028650