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- Title
Sarcoidosis presenting as bilateral optic neuritis after ChAdOx1 nCoV-19 vaccination.
- Authors
Shukla, Amarendra Kumar; Peter, Amrutha; Bhargava, Jitendra Kishore; Arya, Veerendra; Gupta, Manish Kumar; Yadav, Nishtha; Tiwari, Pawan
- Abstract
Sarcoidosis is an idiopathic granulomatous disease and can virtually affect any organ system. Multiple factors, including tubercular antigens organic and environmental exposures, have been implicated in its pathogenesis. In addition to drugs, sarcoid-like reactions have been reported following varicella and influenza vaccination. Few reports of erythema nodosum and Lofgren syndrome have been reported after the COVID-19 vaccination, though no histologic diagnosis was pursued in these cases. We herein report a case of sarcoidosis presenting with bilateral acute onset vision loss with a temporal association with COVID-19 vaccination (ChadOx-1 n-COV, COVISHIELDTM). Symptoms started within two weeks of receiving the vaccine. Alternate causes for optic neuritis were excluded. Transbronchial lung biopsy showed the presence of noncaseating epithelioid cell granulomas. The patient received highdose corticosteroids immediately after diagnosis, albeit with incomplete clinical improvement in vision on a three-month follow-up. In conclusion, we report a novel case of sarcoidosis-related optic neuritis following COVID-19 vaccination.
- Subjects
OPTIC neuritis; SARCOIDOSIS; CHICKENPOX vaccines; COVID-19 vaccines; INFLUENZA vaccines; VACCINATION
- Publication
Monaldi Archives for Chest Disease, 2023, Vol 93, Issue 1, p74
- ISSN
1122-0643
- Publication type
Article
- DOI
10.4081/monaldi.2022.2279